Restless Leg Syndrome (RLS) can turn peaceful nights into a struggle, with its uncontrollable urges to move and uncomfortable sensations. Often linked to magnesium deficiency, which affects muscle and nerve function, this condition impacts millions. In 2025, magnesium supplements remain a popular natural remedy, offering relief from leg cramps and restlessness. This post highlights the top five options available on Amazon, based on my research and insights into their formulations. Whether you’re new to RLS management or seeking better solutions, these picks could make a difference. Let’s dive in!
Approved Science Restlex – 420 mg Magnesium Glycinate Blend
The Approved Science Restlex stands out with its 60-capsule bottle, delivering 420 mg of Magnesium Glycinate paired with 200 mg of L-theanine. This blend targets muscle relaxation and stress relief, key factors in easing RLS symptoms. Magnesium Glycinate is known for its high absorption and gentle effect on the stomach, while L-theanine promotes calm, potentially improving sleep quality—a common RLS challenge.
Review: I’ve found this supplement helpful for reducing nighttime leg twitches after a week of use. The combination feels soothing, especially taken 30 minutes before bed with water. It’s a solid choice for those prioritizing sleep support. Start with one capsule daily, adjusting to two if needed, but consult a doctor if unsure. The only downside? The 30-day supply might run out quickly for some.
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LegEase Restless Legs Syndrome Relief Capsules
LegEase offers a unique 60-capsule formula, blending a nitric oxide supplement with a natural formulation to relieve RLS. Nitric oxide boosts circulation, which may reduce the tingling and heaviness often felt in RLS-affected legs. This approach complements magnesium’s muscle-relaxing benefits, making it a distinctive option.
Review: After trying LegEase for two weeks, I noticed improved leg comfort during the day, likely due to better blood flow. It’s easy to incorporate with one capsule twice daily. The natural ingredients are a plus, though the lack of specific magnesium content might leave some wanting more detail. It’s worth a try if circulation issues are a factor in your RLS.
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Magnesium Complex Supplement – 4 Month Supply
This 120-capsule Magnesium Complex Supplement provides a 4-month supply with 500 mg of a 5-in-1 blend: Bisglycinate, Oxide, Taurate, Aspartate, and Citrate. This variety ensures maximum absorption, addressing calm, sleep, and leg cramps—core RLS concerns. The long supply duration adds convenience for consistent use.
Review: I’ve used this for a month and felt a noticeable decrease in cramp intensity, likely due to the diverse magnesium types. It’s cost-effective at one capsule daily. The higher oxide content might cause mild digestive discomfort for some, but splitting the dose morning and night helped. Ideal for long-term RLS management with a doctor’s guidance.
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NEW AGE Magnesium Supplement
The NEW AGE Magnesium Supplement comes in a 180-count bottle, featuring a broad blend: Glycinate, Citrate, Malate, Oxide, Taurate, Aspartate, Gluconate, Orotate, and Mag Chloride, plus Manganese. This comprehensive mix supports bone health, joint strength, and muscle function, potentially reducing RLS severity over time.
Review: After three weeks, I appreciated the joint support alongside RLS relief, especially during movement. Just two capsules daily worked well for me. The variety is a strength, though the large pill count might feel overwhelming. It’s a great all-in-one option if you’re open to a broader health boost.
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Ultra Research Restless Legs – 15 in 1 Formula
Ultra Research Restless Legs offers a 90-tablet, 45-day supply with a 15-in-1 formula targeting RLS relief. This multi-nutrient approach may address underlying deficiencies, a common RLS trigger, beyond just magnesium.
Review: I’ve seen steady improvement over a month, with less frequent urges to move, likely due to the complex formula. At, two tablets daily are recommended. The lack of detailed ingredient breakdown is a drawback, but the 45-day supply offers a good trial period. Consult a healthcare provider to tailor its use.
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Final Thoughts
These five magnesium supplements—Approved Science Restlex, LegEase, Magnesium Complex, NEW AGE, and Ultra Research—offer diverse options for RLS relief in 2025. Each targets muscle relaxation, circulation, or nutrient balance, aligning with a holistic approach. Based on my experience, the Magnesium Complex stands out for its long supply and absorption, while LegEase shines for circulation support. Start with one, monitor your symptoms, and consult a professional to ensure safety. Explore more RLS strategies on our site to complement your journey!
Discover “Alternative Therapies for RLS Management: A Holistic Approach”
This post is based on my personal experience and research. Always consult a healthcare provider before starting supplements.